Publications in relation to Fraunhofer CIMD

Blache U, Tretbar S, Koehl U, et al, CAR T cells for treating autoimmune diseases, RMD Open 2023;9:e002907. doi: 10.1136/rmdopen-2022-002907

https://rmdopen.bmj.com/content/9/4/e002907.full

 

Meir M, Burkard N, Ungewiß H, Diefenbacher M, Flemming S, Kannapin F, Germer CT, Schweinlin M, Metzger M, Waschke J, Schlegel N. Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease. J Clin Invest. 2019 Jun 17;129(7):2824-2840. doi: 10.1172/JCI120261. PMID: 31205031; PMCID: PMC6597228.

https://www.jci.org/articles/view/120261

 

McInnes IB, Behrens F, Mease PJ, Kavanaugh A, Ritchlin C, Nash P, Masmitja JG, Goupille P, Korotaeva T, Gottlieb AB, Martin R, Ding K, Pellet P, Mpofu S, Pricop L; EXCEED Study Group. Secukinumab versus adalimumab for treatment of active psoriatic arthritis (EXCEED): a double-blind, parallel-group, randomised, active-controlled, phase 3b trial. Lancet. 2020 May 9;395(10235):1496-1505. doi: 10.1016/S0140-6736(20)30564-X. Erratum in: Lancet. 2020 May 30;395(10238):1694. PMID: 32386593.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30564-X/fulltext

 

Sisignano M, Lötsch J, Parnham MJ, Geisslinger G. Potential biomarkers for persistent and neuropathic pain therapy. Pharmacol Ther. 2019 Jul;199:16-29. doi: 10.1016/j.pharmthera.2019.02.004. Epub 2019 Feb 10. PMID: 30759376.

https://www.sciencedirect.com/science/article/abs/pii/S0163725819300178?via%3Dihub

 

Pearson H, Todd EJAA, Ahrends M, Hover SE, Whitehouse A, Stacey M, Lippiat JD, Wilkens L, Fieguth HG, Danov O, Hesse C, Barr JN, Mankouri J. TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection. Thorax. 2021 Jan;76(1):64-72. doi: 10.1136/thoraxjnl-2020-215171. Epub 2020 Oct 27. PMID: 33109690; PMCID: PMC7803913.

https://thorax.bmj.com/content/76/1/64.long

 

Almeida L, Dhillon-LaBrooy A, Castro CN, Adossa N, Carriche GM, Guderian M, Lippens S, Dennerlein S, Hesse C, Lambrecht BN, Berod L, Schauser L, Blazar BR, Kalesse M, Müller R, Moita LF, Sparwasser T. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity. 2021 Jan 12;54(1):68-83.e6. doi: 10.1016/j.immuni.2020.11.001. Epub 2020 Nov 24. PMID: 33238133; PMCID: PMC7837214.

https://www.cell.com/immunity/fulltext/S1074-7613(20)30466-0

 

Klatt-Schreiner K, Valek L, Kang JS, Khlebtovsky A, Trautmann S, Hahnefeld L, Schreiber Y, Gurke R, Thomas D, Wilken-Schmitz A, Wicker S, Auburger G, Geisslinger G, Lötsch J, Pfeilschifter W, Djaldetti R, Tegeder I. High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease. Mov Disord. 2020 Oct;35(10):1822-1833. doi: 10.1002/mds.28186. Epub 2020 Jul 11. PMID: 32652698.

https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28186

 

McInnes IB, Anderson JK, Magrey M, Merola JF, Liu Y, Kishimoto M, Jeka S, Pacheco-Tena C, Wang X, Chen L, Zueger P, Liu J, Pangan AL, Behrens F. Trial of Upadacitinib and Adalimumab for Psoriatic Arthritis. N Engl J Med. 2021 Apr 1;384(13):1227-1239. doi: 10.1056/NEJMoa2022516. PMID: 33789011.

https://www.nejm.org/doi/10.1056/NEJMoa2022516

 

Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schlünzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372(6542):642-646. doi: 10.1126/science.abf7945. Epub 2021 Apr 2. PMID: 33811162; PMCID: PMC8224385. 

https://www.science.org/doi/full/10.1126/science.abf7945

 

Niesel K, Schulz M, Anthes J, Alekseeva T, Macas J, Salamero-Boix A, Möckl A, Oberwahrenbrock T, Lolies M, Stein S, Plate KH, Reiss Y, Rödel F, Sevenich L. The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis. EMBO Mol Med. 2021 May 7;13(5):e13412. doi: 10.15252/emmm.202013412. Epub 2021 Mar 23. PMID: 33755340; PMCID: PMC8103101.

https://www.embopress.org/doi/full/10.15252/emmm.202013412

 

Lapuente D, Fuchs J, Willar J, Vieira Antão A, Eberlein V, Uhlig N, Issmail L, Schmidt A, Oltmanns F, Peter AS, Mueller-Schmucker S, Irrgang P, Fraedrich K, Cara A, Hoffmann M, Pöhlmann S, Ensser A, Pertl C, Willert T, Thirion C, Grunwald T, Überla K, Tenbusch M. Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization. Nat Commun. 2021 Nov 26;12(1):6871. doi: 10.1038/s41467-021-27063-4. PMID: 34836955; PMCID: PMC8626513.

https://www.nature.com/articles/s41467-021-27063-4

 

Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N; GRADS Investigators. Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. Eur Respir J. 2021 Dec 2;58(6):2002950. doi: 10.1183/13993003.02950-2020. PMID: 34083402; PMCID: PMC9759791.

https://erj.ersjournals.com/content/58/6/2002950.long

 

Gottlieb AB, Merola JF, Reich K, Behrens F, Nash P, Griffiths CEM, Bao W, Pellet P, Pricop L, McInnes IB. Efficacy of secukinumab and adalimumab in patients with psoriatic arthritis and concomitant moderate-to-severe plaque psoriasis: results from EXCEED, a randomized, double-blind head-to-head monotherapy study. Br J Dermatol. 2021 Dec;185(6):1124-1134. doi: 10.1111/bjd.20413. Epub 2021 Jul 14. PMID: 33913511; PMCID: PMC9291158.

https://academic.oup.com/bjd/article-lookup/doi/10.1111/bjd.20413

 

Valek L, Tran B, Wilken-Schmitz A, Trautmann S, Heidler J, Schmid T, Brüne B, Thomas D, Deller T, Geisslinger G, Auburger G, Tegeder I. Prodromal sensory neuropathy in Pink1-/- SNCAA53T double mutant Parkinson mice. Neuropathol Appl Neurobiol. 2021 Dec;47(7):1060-1079. doi: 10.1111/nan.12734. Epub 2021 May 28. PMID: 33974284.

https://onlinelibrary.wiley.com/doi/10.1111/nan.12734

 

Ge C, Weisse S, Xu B, Dobritzsch D, Viljanen J, Kihlberg J, Do NN, Schneider N, Lanig H, Holmdahl R, Burkhardt H. Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor. Ann Rheum Dis. 2022 Apr;81(4):480-489. doi: 10.1136/annrheumdis-2021-220500. Epub 2022 Jan 13. PMID: 35027402; PMCID: PMC8921575.

https://ard.bmj.com/content/81/4/480.long

 

Königs V, Pierre S, Schicht M, Welss J, Hahnefeld L, Rimola V, Lütjen-Drecoll E, Geisslinger G, Scholich K. GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression. Diabetes. 2022 Apr 1;71(4):774-787. doi: 10.2337/db21-0711. PMID: 35061031.

https://diabetesjournals.org/diabetes/article/71/4/774/140941/GPR40-Activation-Abolishes-Diabetes-Induced

 

Kristensen LE, Keiserman M, Papp K, McCasland L, White D, Lu W, Wang Z, Soliman AM, Eldred A, Barcomb L, Behrens F. Efficacy and safety of risankizumab for active psoriatic arthritis: 24-week results from the randomised, double-blind, phase 3 KEEPsAKE 1 trial. Ann Rheum Dis. 2022 Feb;81(2):225-231. doi: 10.1136/annrheumdis-2021-221019. Epub 2021 Dec 15. PMID: 34911706; PMCID: PMC8762015.

https://ard.bmj.com/content/81/2/225.long

 

Mease PJ, Deodhar AA, van der Heijde D, Behrens F, Kivitz AJ, Neal J, Kim J, Singhal S, Nowak M, Banerjee S. Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, in a phase II trial in psoriatic arthritis. Ann Rheum Dis. 2022 Jun;81(6):815-822. doi: 10.1136/annrheumdis-2021-221664. Epub 2022 Mar 3. PMID: 35241426; PMCID: PMC9120409.

https://ard.bmj.com/content/81/6/815.long

 

Sisignano M, Gribbon P, Geisslinger G. Drug Repurposing to Target Neuroinflammation and Sensory Neuron-Dependent Pain. Drugs. 2022 Mar;82(4):357-373. doi: 10.1007/s40265-022-01689-0. Epub 2022 Mar 7. PMID: 35254645; PMCID: PMC8899787.

https://link.springer.com/article/10.1007/s40265-022-01689-0

 

Schaffert A, Karkossa I, Ueberham E, Schlichting R, Walter K, Arnold J, Blüher M, Heiker JT, Lehmann J, Wabitsch M, Escher BI, von Bergen M, Schubert K. Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes. Environ Int. 2022 Jun;164:107279. doi: 10.1016/j.envint.2022.107279. Epub 2022 May 6. PMID: 35567983.

https://www.sciencedirect.com/science/article/pii/S0160412022002069

 

Chauvistré H, Shannan B, Daignault-Mill SM, Ju RJ, Picard D, Egetemaier S, Váraljai R, Gibhardt CS, Sechi A, Kaschani F, Keminer O, Stehbens SJ, Liu Q, Yin X, Jeyakumar K, Vogel FCE, Krepler C, Rebecca VW, Kubat L, Lueong SS, Forster J, Horn S, Remke M, Ehrmann M, Paschen A, Becker JC, Helfrich I, Rauh D, Kaiser M, Gul S, Herlyn M, Bogeski I, Rodríguez-López JN, Haass NK, Schadendorf D, Roesch A. Persister state-directed transitioning and vulnerability in melanoma. Nat Commun. 2022 Jun 1;13(1):3055. doi: 10.1038/s41467-022-30641-9. PMID: 35650266; PMCID: PMC9160289.

https://www.nature.com/articles/s41467-022-30641-9

 

Endle H, Horta G, Stutz B, Muthuraman M, Tegeder I, Schreiber Y, Snodgrass IF, Gurke R, Liu ZW, Sestan-Pesa M, Radyushkin K, Streu N, Fan W, Baumgart J, Li Y, Kloss F, Groppa S, Opel N, Dannlowski U, Grabe HJ, Zipp F, Rácz B, Horvath TL, Nitsch R, Vogt J. AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids. Nat Metab. 2022 Jun;4(6):683-692. doi: 10.1038/s42255-022-00589-7. Epub 2022 Jun 27. PMID: 35760867; PMCID: PMC9940119.

https://www.nature.com/articles/s42255-022-00589-7

 

Mease PJ, Deodhar AA, van der Heijde D, Behrens F, Kivitz AJ, Neal J, Kim J, Singhal S, Nowak M, Banerjee S. Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, in a phase II trial in psoriatic arthritis. Ann Rheum Dis. 2022 Jun;81(6):815-822. doi: 10.1136/annrheumdis-2021-221664. Epub 2022 Mar 3. PMID: 35241426; PMCID: PMC9120409.

https://ard.bmj.com/content/81/6/815.long

 

Shin J, Kovacheva L, Thomas D, Stojanovic S, Knowlton CJ, Mankel J, Boehm J, Farassat N, Paladini C, Striessnig J, Canavier CC, Geisslinger G, Roeper J. Cav1.3 calcium channels are full-range linear amplifiers of firing frequencies in lateral DA SN neurons. Sci Adv. 2022 Jun 10;8(23):eabm4560. doi: 10.1126/sciadv.abm4560. Epub 2022 Jun 8. PMID: 35675413; PMCID: PMC9177074.

https://www.science.org/doi/10.1126/sciadv.abm4560

 

Alharbi E, Gadiya Y, Henderson D, Zaliani A, Delfin-Rossaro A, Cambon-Thomsen A, Kohler M, Witt G, Welter D, Juty N, Jay C, Engkvist O, Goble C, Reilly DS, Satagopam V, Ioannidis V, Gu W, Gribbon P. Selection of data sets for FAIRification in drug discovery and development: Which, why, and how? Drug Discov Today. 2022 Aug;27(8):2080-2085. doi: 10.1016/j.drudis.2022.05.010. Epub 2022 May 17. PMID: 35595012; PMCID: PMC9236643.

https://www.sciencedirect.com/science/article/pii/S1359644622001994

 

Royzman D, Andreev D, Stich L, Peckert-Maier K, Wild AB, Zinser E, Mühl-Zürbes P, Jones E, Adam S, Frey S, Fuchs M, Kunz M, Bäuerle T, Nagel L, Schett G, Bozec A, Steinkasserer A. The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis. Front Immunol. 2022 Aug 8;13:936995. doi: 10.3389/fimmu.2022.936995. PMID: 36003376; PMCID: PMC9393726.

https://www.frontiersin.org/articles/10.3389/fimmu.2022.936995/full

 

Blache U, Popp G, Dünkel A, Koehl U, Fricke S. Potential solutions for manufacture of CAR T cells in cancer immunotherapy. Nat Commun. 2022 Sep 5;13(1):5225. doi: 10.1038/s41467-022-32866-0. PMID: 36064867; PMCID: PMC9445013.

https://www.nature.com/articles/s41467-022-32866-0

 

Gurke R, Bendes A, Bowes J, Koehm M, Twyman RM, Barton A, Elewaut D, Goodyear C, Hahnefeld L, Hillenbrand R, Hunter E, Ibberson M, Ioannidis V, Kugler S, Lories RJ, Resch E, Rüping S, Scholich K, Schwenk JM, Waddington JC, Whitfield P, Geisslinger G, FitzGerald O, Behrens F, Pennington SR; HIPPOCRATES Consortium. Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis. Biomedicines. 2022 Sep 24;10(10):2387. doi: 10.3390/biomedicines10102387. PMID: 36289648; PMCID: PMC9598654.

https://www.mdpi.com/2227-9059/10/10/2387

 

Wedel S, Mathoor P, Rauh O, Heymann T, Ciotu CI, Fuhrmann DC, Fischer MJM, Weigert A, de Bruin N, Hausch F, Geisslinger G, Sisignano M. SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain. J Neuroinflammation. 2022 Oct 10;19(1):254. doi: 10.1186/s12974-022-02615-7. PMID: 36217203; PMCID: PMC9552419.

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-022-02615-7

 

Berg H, Wirtz Martin MA, Altincekic N, Alshamleh I, Kaur Bains J, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C, Gande SL, Hargittay B, Hohmann KF, Hutchison MT, Marianne Korn S, Krishnathas R, Kutz F, Linhard V, Matzel T, Meiser N, Niesteruk A, Pyper DJ, Schulte L, Trucks S, Azzaoui K, Blommers MJJ, Gadiya Y, Karki R, Zaliani A, Gribbon P, da Silva Almeida M, Dinis Anobom C, Bula AL, Bütikofer M, Putinhon Caruso Í, Caterina Felli I, Da Poian AT, Cardoso de Amorim G, Fourkiotis NK, Gallo A, Ghosh D, Gomes-Neto F, Gorbatyuk O, Hao B, Kurauskas V, Lecoq L, Li Y, Cunha Mebus-Antunes N, Mompeán M, Cristtina Neves-Martins T, Ninot-Pedrosa M, Pinheiro AS, Pontoriero L, Pustovalova Y, Riek R, Robertson AJ, Jose Abi Saad M, Treviño MÁ, Tsika AC, Almeida FCL, Bax A, Henzler-Wildman K, Hoch JC, Jaudzems K, Laurents DV, Orts J, Pierattelli R, Spyroulias GA, Duchardt-Ferner E, Ferner J, Fürtig B, Hengesbach M, Löhr F, Qureshi N, Richter C, Saxena K, Schlundt A, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J, Schwalbe H. Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development. Angew Chem Int Ed Engl. 2022 Nov 14;61(46):e202205858. doi: 10.1002/anie.202205858. Epub 2022 Oct 13. PMID: 36115062; PMCID: PMC9539013.

https://onlinelibrary.wiley.com/doi/10.1002/anie.202205858

 

Kolbinger A, Schäufele TJ, Steigerwald H, Friedel J, Pierre S, Geisslinger G, Scholich K. Eosinophil-derived IL-4 is necessary to establish the inflammatory structure in innate inflammation. EMBO Mol Med. 2023 Feb 8;15(2):e16796. doi: 10.15252/emmm.202216796. Epub 2022 Dec 21. PMID: 36541656; PMCID: PMC9906331.

https://www.embopress.org/doi/full/10.15252/emmm.202216796

 

Merola JF, Landewé R, McInnes IB, Mease PJ, Ritchlin CT, Tanaka Y, Asahina A, Behrens F, Gladman DD, Gossec L, Gottlieb AB, Thaçi D, Warren RB, Ink B, Assudani D, Bajracharya R, Shende V, Coarse J, Coates LC. Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor-α inhibitors: a randomised, double-blind, placebo-controlled, phase 3 trial (BE COMPLETE). Lancet. 2023 Jan 7;401(10370):38-48. doi: 10.1016/S0140-6736(22)02303-0. Epub 2022 Dec 6. PMID: 36495881.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02303-0/fulltext

 

Sisignano M, Geisslinger G. Rethinking the use of NSAIDs in early acute pain. Trends Pharmacol Sci. 2023 Apr;44(4):193-195. doi: 10.1016/j.tips.2023.01.001. Epub 2023 Jan 26. PMID: 36707386.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(23)00016-0