Ausgewählte Publikationen mit Bezug zum Fraunhofer CIMD

2024

1.      Ri K, Weng TH, Claveras Cabezudo A, Jösting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S. Molecular mechanism of choline and ethanolamine transport in humans. Nature. 2024 May 22. doi: 10.1038/s41586-024-07444-7. Epub ahead of print. PMID: 38778100.

2.      Eberlein V, Rosencrantz S, Finkensieper J, Besecke JK, Mansuroglu Y, Kamp JC, Lange F, Dressman J, Schopf S, Hesse C, Thoma M, Fertey J, Ulbert S, Grunwald T. Mucosal immunization with a low-energy electron inactivated respiratory syncytial virus vaccine protects mice without Th2 immune bias. Front Immunol. 2024 Apr 5;15:1382318. doi: 10.3389/fimmu.2024.1382318. PMID: 38646538; PMCID: PMC11026718.

3.      Beneke V, Grieger KM, Hartwig C, Müller J, Sohn K, Blaudszun AR, Hilger N, Schaudien D, Fricke S, Braun A, Sewald K, Hesse C. Homeostatic T helper 17 cell responses triggered by complex microbiota are maintained in ex vivo intestinal tissue slices. Eur J Immunol. 2024 May 19:e2350946. doi: 10.1002/eji.202350946. Epub ahead of print. PMID: 38763899.

4.      Kugler S, Hahnefeld L, Kloka JA, Ginzel S, Nürenberg-Goloub E, Zinn S, Vehreschild MJ, Zacharowski K, Lindau S, Ullrich E, Burmeister J, Kohlhammer J, Schwäble J, Gurke R, Dorochow E, Bennett A, Dauth S, Campe J, Knape T, Laux V, Kannt A, Köhm M, Geisslinger G, Resch E, Behrens F. Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units. Talanta. 2024 Feb 1;268(Pt 1):125295. doi: 10.1016/j.talanta.2023.125295. Epub ahead of print. PMID: 37866305.

5.      Tretbar, U.S., Rurik, J.G., Rustad, E.H. et al. Non-viral vectors for chimeric antigen receptor immunotherapy. Nat Rev Methods Primers 4, 74 (2024). https://doi.org/10.1038/s43586-024-00348-w

6.      Frank K, Mengesdorf T, Radić M, Herrmann P, Appenzeller A, Mucha H, Orak B, Spiecker Gen Döhmann I, Rüping S, Burkhardt H, Köhm M, Dauth S. Sharing for Caring? A Patients' and Clinicians' View on Handling Personal Medical Data in the Context of Digitization: An Exploratory Study. Healthcare (Basel). 2024 Oct 16;12(20):2053. doi: 10.3390/healthcare12202053. PMID: 39451469; PMCID: PMC11507340.

7.      Sens A, Thomas D, Schäfer SMG, König A, Pinter A, Tegeder I, Geisslinger G, Gurke R. Endocannabinoid analysis in GlucoEXACT plasma: Method validation and sample handling recommendations. Talanta. 2024 Oct 1;278:126518. doi: 10.1016/j.talanta.2024.126518. Epub 2024 Jul 5. PMID: 39018759.

8.      Lötsch J, Gasimli K, Malkusch S, Hahnefeld L, Angioni C, Schreiber Y, Trautmann S, Wedel S, Thomas D, Ferreiros Bouzas N, Brandts CH, Schnappauf B, Solbach C, Geisslinger G, Sisignano M. Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients. Elife. 2024 Sep 30;13:RP91941. doi: 10.7554/eLife.91941. PMID: 39347767; PMCID: PMC11444680.

9.      Abbas N, Bentele M, Waleczek FJG, Fuchs M, Just A, Pfanne A, Pich A, Linke S, Neumüller S, Stucki-Koch A, Jordan M, Perbellini F, Werlein C, Korte W, Ius F, Ruhparwar A, Weber N, Fiedler J, Thum T. Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine. J Mol Cell Cardiol. 2024 Sep 26;196:125-140. doi: 10.1016/j.yjmcc.2024.09.012. Epub ahead of print. PMID: 39341589.

10.   Betz LT, Jacob GA, Knitza J, Koehm M, Behrens F. Efficacy of a cognitive- behavioral digital therapeutic on psychosocial outcomes in rheumatoid arthritis: randomized controlled trial. Npj Ment Health Res. 2024 Sep 3;3(1):41. doi: 10.1038/s44184-024-00085-8. PMID: 39227501; PMCID: PMC11371912.

11.   Sommer C, Jacob S, Bargmann T, Shoaib M, Alshaikhdeeb B, Satagopam VP, Dehmel S, Neuhaus V, Braun A, Sewald K. Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology. Clin Immunol. 2024 Sep;266:110288. doi: 10.1016/j.clim.2024.110288. Epub 2024 Jun 29. PMID: 38950723.

Beteiligte Institute des Clusters: Fraunhofer ITEM

12.   Rischke S, Schäfer SMG, König A, Ickelsheimer T, Köhm M, Hahnefeld L, Zaliani A, Scholich K, Pinter A, Geisslinger G, Behrens F, Gurke R. Metabolomic and lipidomic fingerprints in inflammatory skin diseases - Systemic illumination of atopic dermatitis, hidradenitis suppurativa and plaque psoriasis. Clin Immunol. 2024 Aug;265:110305. doi: 10.1016/j.clim.2024.110305. Epub 2024 Jul 5. PMID: 38972618.

13.   Fischer C, Schreiber Y, Nitsch R, Vogt J, Thomas D, Geisslinger G, Tegeder I. Lysophosphatidic Acid Receptors LPAR5 and LPAR2 Inversely Control Hydroxychloroquine-Evoked Itch and Scratching in Mice. Int J Mol Sci. 2024 Jul 26;25(15):8177. doi: 10.3390/ijms25158177. PMID: 39125747; PMCID: PMC11312285.

14.   Dauth S, Foldenauer AC, Hallmann K, Kunz C, König A, Haferland I, Möser C, Koehm M, Pinter A. Brodalumab is Effective for Psoriasis Patients with Difficult-to-treat Body Regions: Results from an Observational Clinical Study. Dermatology. 2024 Nov 6:1-12. doi: 10.1159/000542348. Epub ahead of print. PMID: 39504944.

15.   Sommer C, Neuhaus V, Gogesch P, Flandre T, Dehmel S, Sewald K. Type 2 responses determine skin rash during recombinant interleukin-2 therapy. J Immunotoxicol. 2024 Oct;21(sup1):S48-S59. doi: 10.1080/1547691X.2024.2343359. Epub 2024 Dec 10. PMID: 39655497.

16.   Hahnefeld L, Hackel J, Trautmann S, Angioni C, Schreiber Y, Gurke R, Thomas D, Wicker S, Geisslinger G, Tegeder I. Healthy plasma lipidomic signatures depend on sex, age, body mass index, and contraceptives but not perceived stress. Am J Physiol Cell Physiol. 2024 Dec 1;327(6):C1462-C1480. doi: 10.1152/ajpcell.00630.2024. Epub 2024 Oct 22. PMID: 39437447.

2023

1.       Sisignano M, Geisslinger G. Rethinking the use of NSAIDs in early acute pain. Trends Pharmacol 2023 Apr;44(4):193-195. doi: 10.1016/j.tips.2023.01.001. Epub 2023 Jan 26. PMID: 36707386

2.      Koehm M, Rossmanith T, Foldenauer AC, Herrmann E, Brandt-Jürgens J, Burmester GR, Kellner H, Kiltz U, Kofler DM, Rech J, Mojtahed-Poor S, Jonetzko C, Burkhardt H, Behrens F; MUST Investigator Group. Methotrexate plus ustekinumab versus ustekinumab monotherapy in patients with active psoriatic arthritis (MUST): a randomised, multicentre, placebo-controlled, phase 3b, non-inferiority trial. Lancet Rheumatol. 2023 Jan;5(1):e14-e23. doi: 10.1016/S2665-9913(22)00329-0. PMID: 38251504.

3.      Sens A, Rischke S, Hahnefeld L, Dorochow E, Schäfer SMG, Thomas D, Köhm M, Geisslinger G, Behrens F, Gurke R. Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS- based clinical research. J Mass Spectrom Adv Clin Lab. 2023 Feb 17;28:35-46. doi: 10.1016/j.jmsacl.2023.02.002. PMID: 36872954; PMCID: PMC9975683.

4.      Schmidt JR, Haupt J, Riemschneider S, Kämpf C, Löffler D, Blumert C, Reiche K, Koehl U, Kalkhof S, Lehmann J. Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages. Front Immunol. 2023 May 23;14:1156493. doi: 10.3389/fimmu.2023.1156493. PMID: 37287978; PMCID: PMC10242070.

5.      Koehm M, Klippstein M, Dauth S, Hallmann K, Kohmer N, Burkhardt H, Ciesek S, Geisslinger G, Rabenau HF, Behrens F. Impact of different classes of immune- modulating treatments on B cell-related and T cell-related immune response before and after COVID-19 booster vaccination in patients with immune-mediated diseases and primary immunodeficiency: a cohort study. RMD Open. 2023 Aug;9(3):e003094. doi: 10.1136/rmdopen-2023-003094. PMID: 37652553; PMCID: PMC10476126.

6.      Eberlein V, Ahrends M, Bayer L, Finkensieper J, Besecke JK, Mansuroglu Y, Standfest B, Lange F, Schopf S, Thoma M, Dressman J, Hesse C, Ulbert S, Grunwald T. Mucosal Application of a Low-Energy Electron Inactivated Respiratory Syncytial Virus Vaccine Shows Protective Efficacy in an Animal Model. Viruses. 2023 Aug 30;15(9):1846. doi: 10.3390/v15091846. PMID: 37766253; PMCID: PMC10535182.

7.      FitzGerald O, Behrens F, Barton A, Bertheussen H, Boutouyrie-Dumont B, Coates L, Davies O, de Wit M, Fagni F, Goodyear CS, Gurke R, Hahnefeld L, Huppertz C, Ioannidis V, Ibberson M, Katz A, Klippstein M, Koehm M, Korish S, Mackay S, Martin DA, O'Sullivan D, Patel K, Rueping S, Schett G, Scholich K, Schwenk JM, Siebert S, Simon D, Vivekanantham A, Pennington SR. Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis. Ther Adv Musculoskelet Dis. 2023 Sep 8;15:1759720X231192315. doi: 10.1177/1759720X231192315. PMID: 37694182; PMCID: PMC10492462.

8.      von Auw N, Serfling R, Kitte R, Hilger N, Zhang C, Gebhardt C, Duenkel A, Franz P, Koehl U, Fricke S, Tretbar US. Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality. Sci Rep. 2023 Oct 24;13(1):18160. doi: 10.1038/s41598-023-45197-x. PMID: 37875523; PMCID: PMC10598065.

9.      Zerweck L, Wesarg S, Kohlhammer J, Köhm M. Combining seeded region growing and k-nearest neighbours for the segmentation of routinely acquired spatio- temporal image data. Int J Comput Assist Radiol Surg. 2023 Nov;18(11):2063-2072. doi: 10.1007/s11548-023-02951-w. Epub 2023 Jun 4. PMID: 37270742; PMCID: PMC10589180.

10.   Blache U, Tretbar S, Koehl U, Mougiakakos D, Fricke S. CAR T cells for treating autoimmune diseases. RMD Open. 2023 Nov 23;9(4):e002907. doi: 10.1136/rmdopen-2022-002907. PMID: 37996128; PMCID: PMC10668249.